Interpretation of epicardial mapping by means of computer simulations: Applications to calcium, lidocaine and to BRL 34915
Identifieur interne : 004570 ( Main/Exploration ); précédent : 004569; suivant : 004571Interpretation of epicardial mapping by means of computer simulations: Applications to calcium, lidocaine and to BRL 34915
Auteurs : P. Auger [France] ; R. Cardinal [Canada] ; A. Bril ; L. Rochette ; A. BardouSource :
- Acta Biotheoretica [ 0001-5342 ] ; 1992-09-01.
Abstract
Abstract: The aim of this work was to compare experimental investigations on effects of lidocaine, calcium and, BRL 34915 on reentries to simulated data obtained by use of a model of propagation based on the Huygens' constriction method already described in previous works. Calcium and lidocaine effects are investigated on anisotropic conduction conditions. In both cases, reduction in conduction velocities are observed. In lidocaine case, a refractory area is located along the longitudinal axis. In agreement with experimental electrical mapping, the simulations show that the stabilization of reentrant excitation is mainly due to the existence of this refractory area around which the reentrant circuit can develop. The experimental study shows that BRL 34915 has both arrhythmogenic and antiarrhythmic effects. A detailed electrophysiological analysis has shown that drug infusion act on normal cardiac cells by decreasing the relative and absolute refractory period. BRL 34915 action is simulated by a decrease in the refractory period showing that the time frequency of the reentrant activity is increased and that the spatial size where the reentry is developing is becoming smaller. These two effects are arrhythmogenic, the simulated data being so in good agreement with the experimental ones.
Url:
DOI: 10.1007/BF00168145
Affiliations:
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Bardou</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:20B72B9BAD3AD36C5BF0C611221D0B284285D1C0</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1007/BF00168145</idno><idno type="url">https://api-v5.istex.fr/document/20B72B9BAD3AD36C5BF0C611221D0B284285D1C0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002203</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002203</idno><idno type="wicri:Area/Istex/Curation">002203</idno><idno type="wicri:Area/Istex/Checkpoint">001E18</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001E18</idno><idno type="wicri:doubleKey">0001-5342:1992:Auger P:interpretation:of:epicardial</idno><idno type="wicri:Area/Main/Merge">004E20</idno><idno type="wicri:Area/Main/Curation">004570</idno><idno type="wicri:Area/Main/Exploration">004570</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Interpretation of epicardial mapping by means of computer simulations: Applications to calcium, lidocaine and to BRL 34915</title><author><name sortKey="Auger, P" sort="Auger, P" uniqKey="Auger P" first="P." last="Auger">P. 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Bril</name><affiliation><wicri:noCountry code="subField">Dijon</wicri:noCountry></affiliation></author><author><name sortKey="Rochette, L" sort="Rochette, L" uniqKey="Rochette L" first="L." last="Rochette">L. Rochette</name><affiliation><wicri:noCountry code="subField">Dijon</wicri:noCountry></affiliation></author><author><name sortKey="Bardou, A" sort="Bardou, A" uniqKey="Bardou A" first="A." last="Bardou">A. Bardou</name><affiliation><wicri:noCountry code="subField">14</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Biotheoretica</title><title level="j" type="sub">An international journal on the mathematical and philosophical foundations of biological and biomedical science</title><title level="j" type="abbrev">Acta Biotheor</title><idno type="ISSN">0001-5342</idno><idno type="eISSN">1572-8358</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1992-09-01">1992-09-01</date><biblScope unit="volume">40</biblScope><biblScope unit="issue">2-3</biblScope><biblScope unit="page" from="161">161</biblScope><biblScope unit="page" to="168">168</biblScope></imprint><idno type="ISSN">0001-5342</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-5342</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The aim of this work was to compare experimental investigations on effects of lidocaine, calcium and, BRL 34915 on reentries to simulated data obtained by use of a model of propagation based on the Huygens' constriction method already described in previous works. Calcium and lidocaine effects are investigated on anisotropic conduction conditions. In both cases, reduction in conduction velocities are observed. In lidocaine case, a refractory area is located along the longitudinal axis. In agreement with experimental electrical mapping, the simulations show that the stabilization of reentrant excitation is mainly due to the existence of this refractory area around which the reentrant circuit can develop. The experimental study shows that BRL 34915 has both arrhythmogenic and antiarrhythmic effects. A detailed electrophysiological analysis has shown that drug infusion act on normal cardiac cells by decreasing the relative and absolute refractory period. BRL 34915 action is simulated by a decrease in the refractory period showing that the time frequency of the reentrant activity is increased and that the spatial size where the reentry is developing is becoming smaller. These two effects are arrhythmogenic, the simulated data being so in good agreement with the experimental ones.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li></region><settlement><li>Dijon</li></settlement><orgName><li>Université de Bourgogne</li></orgName></list><tree><noCountry><name sortKey="Bardou, A" sort="Bardou, A" uniqKey="Bardou A" first="A." last="Bardou">A. Bardou</name><name sortKey="Bril, A" sort="Bril, A" uniqKey="Bril A" first="A." last="Bril">A. Bril</name><name sortKey="Rochette, L" sort="Rochette, L" uniqKey="Rochette L" first="L." last="Rochette">L. Rochette</name></noCountry><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Auger, P" sort="Auger, P" uniqKey="Auger P" first="P." last="Auger">P. Auger</name></region></country><country name="Canada"><noRegion><name sortKey="Cardinal, R" sort="Cardinal, R" uniqKey="Cardinal R" first="R." last="Cardinal">R. Cardinal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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